Discovery to improve the lives of brain tumor patients

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Discovery to improve the lives of brain tumor patients

    • THE KIM LABORATORY

      Washington University School of Medicine

      Neurological Surgery

    • news

      New findings and notable events from the Kim lab

    • The problem of glioblastoma

      Glioblastoma is the most common malignant primary brain tumor in adults. Despite aggressive surgical resection, chemotherapy, and radiation therapy, this disease remains challenging with no cure. We are interested in the molecular mechanisms that control key features of glioblastoma biology. The long-term goal of my laboratory is to leverage these insights for the rational design of novel strategies against this formidable disease.

      GENETICS

      Our laboratory is interested in developing new strategies to accurately profile patient tumors, including multisector and region-specific approaches. We are also focused on establishing new experimental model systems (both mouse and human) using canonical tumor mutations.

      EPIGENETICS

      Glioblastoma stem-like cells represent a dynamic cell state influenced by cell-intrinsic and -extrinsic cues. Our laboratory is interested in finding ways to disrupt the epigenetic state that defines these tumor-initiating cells. We are pursuing a variety of approaches, including high-throughput screening, pharmacology, biochemistry, genetics and material engineering, to accomplish this goal. A major thematic focus is mechanisms of protein homeostasis which affect the malignant epigenetic state.

      METABOLISM

      Cancer cells exhibit a dependency on metabolic pathways regulated by nicotinamide adenine dinucleotide (NAD+), which has a well-known role in oxidation-reduction reactions and is an essential component of signaling pathways as a co-factor for NAD+-dependent enzymes. The rate-limiting enzyme in NAD+ synthesis, NAMPT, is highly expressed in glioblastoma tumors. How the regulation of this enzyme interfaces with NAD+-dependent signal transduction networks remains poorly understood in glioblastoma.

    • Our Team

      Albert H. Kim, MD, PhD

      Principal Investigator

      Neurosurgeon-scientist specializing in complex brain tumors

      Diane Mao, MD

      Lab Manager

      Devi Annamalai, PhD

      Post-doctoral Fellow

      Dan Hafez, MD, PhD

      Post-doctoral Fellow

      Neurosurgical Resident

      Lab Social Chair

      Bhuvic Patel, MD

      Post-doctoral Fellow

      Neurosurgical Resident

      Afshin Salehi, MD

      Post-doctoral Fellow

      Neurosurgical Resident

      Former Lab Social Chair

      Xuan Qu

      MD-PhD Student

      Patrick DeSouza

      MD-PhD Student

      Tatenda Mahlokozera

      MD-PhD Student

      Hao Chen

      PhD Student

      Mounica Paturu

      MD Student

    • Alumni

      Undergraduate Students

      Alice Turski (2012-2014). Received 2013 Summer Undergraduate Research Fellowship to work in my laboratory.

      John Finlay (Summer 2015).

      Simon Gunter (2015-2016).

      Ross Buchman (Summer 2019).

       

      Medical Students

      Sam Sun (2013-2016). Received the Alpha Omega Alpha Award (2013) and American Brain Tumor Association Summer Fellowship (2014) to work in my lab.

      Ishita Chen (Summer 2013).

      Diane Aum (2014-2016). Received the David Silbert Summer Research Fellowship to work in my laboratory.

      Ramin Lalezari (2014-2016).

      David Dadey (2016-2017).

      Ioana Flores (2017).

      Mounica Pataru (2016-2019). Awarded a NREF Summer Research Fellowship.

      Rukayat Taiwo (2017-2019). Awarded a HHMI Medical Fellowship

       

      Post-doctoral Fellows

      Amit Gujar, PhD (2012-2017). Currently a Staff Scientist in Roel Verhaak Lab, Jackson Laboratories, CT.

      Peter Sylvester, MD (2013-2017). Resident in Neurological Surgery, Washington University.

      Ananth Vellimana, MD (2014-2018). Resident in Neurological Surgery, Washington University.

      Ashwin Kamath, MD (2014-2018). Resident in Neurological Surgery, Washington University.

      Zohny Zohny, MD (2014-2017). Currently a Fellow in Neurological Surgery, Saint Louis University.

      Thomas Beaumont, MD (2014-2016).

      Rory Murphy, MD (2013-2016).

      Santhi Pondugula, PhD (2014-2017).

      Brendan Fong, MD (2017-2019)

    • Publications

      2019

      1. Taylor JW, Armstrong T, Kim AH, Venere M, Acquaye A, Schrag D, Wen PY. The lomustine crisis: awareness and impact of the 1500% price hike. Neuro Oncol. 2019 Jan 1;21(1):1-3. doi: 10.1093/neuonc/noy189. PubMed PMID: 30590836; PubMed Central PMCID: PMC6303421.
      2. Yang W, Warrington NM, Taylor SJ, Whitmire P, Carrasco E, Singleton KW, Wu N, Lathia JD, Berens ME, Kim AH, Barnholtz-Sloan JS, Swanson KR, Luo J, Rubin JB.Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data. Sci Transl Med. 2019 Jan 2;11(473). doi: 10.1126/scitranslmed.aao5253. PubMed PMID: 30602536; PubMed Central PMCID: PMC6502224.
      3. Kamath AA, Friedman DD, Akbari SHA, Kim AH, Tao Y, Luo J, Leuthardt EC.Glioblastoma Treated With Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy: Safety, Efficacy, and Outcomes. Neurosurgery. 2019 Apr 1;84(4):836-843. doi: 10.1093/neuros/nyy375. PubMed PMID: 30137606; PubMed Central PMCID: PMC6425465.
      4. Silverstein JM, Goss CW, Kim AH. In Reply: Withholding Perioperative Steroids in Patients Undergoing Transsphenoidal Resection for Pituitary Disease: Randomized Prospective Clinical Trial to Assess Safety. Neurosurgery. 2019 Apr 15;. doi: 10.1093/neuros/nyz108. [Epub ahead of print] PubMed PMID: 30989222.
      5. Rennert RC, Khan U, Bartek J, Tatter SB, Field M, Toyota B, Fecci PE, Judy K, Mohammadi AM, Landazuri P, Sloan AE, Kim AH, Leuthardt EC, Chen CC. Laser Ablation of Abnormal Neurological Tissue Using Robotic Neuroblate System (LAANTERN): Procedural Safety and Hospitalization. Neurosurgery. 2019 May 11;. doi: 10.1093/neuros/nyz141. [Epub ahead of print] PubMed PMID: 31076762.

      2018

      1. Strowd RE, Kim AH, Wen PY. Meeting Update-Society for Neuro-Oncology 2017 Annual Meeting. Neuro Oncol. 2018 Jan 22;20(2):156-159. PubMed PMID: 29365203; PubMed Central PMCID: PMC5777479.
      2. Barrow AD, Edeling MA, Trifonov V, Luo J, Goyal P, Bohl B, Bando JK, Kim AH, Walker J, Andahazy M, Bugatti M, Melocchi L, Vermi W, Fremont DH, Cox S, Cella M, Schmedt C, Colonna M. Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor. Cell. 2018 Jan 25;172(3):534-548.e19. PubMed PMID: 29275861.
      3. Reynolds MR, Arias EJ, Derdeyn CP, Kim AH. Transorbital intracranial penetrating trauma with carotid artery injury: a multidisciplinary approach to management. J Neurosurg Sci. 2018 Feb;62(1):89-91. PubMed PMID: 29239162.
      4. Mahlokozera T, Vellimana AK, Li T, Mao DD, Zohny ZS, Kim DH, Tran DD, Marcus DS, Fouke SJ, Campian JL, Dunn GP, Miller CA, Kim AH. Biological and therapeutic implications of multisector sequencing in newly diagnosed glioblastoma. Neuro Oncol. 2018 Mar 27;20(4):472-483. PubMed PMID: 29244145; PubMed Central PMCID: PMC5909635.
      5. Abraham C, Garsa A, Badiyan SN, Drzymala R, Yang D, DeWees T, Tsien C, Dowling JL, Rich KM, Chicoine MR, Kim AH, Leuthardt EC, Robinson C. Internal dose escalation is associated with increased local control for non-small cell lung cancer (NSCLC) brain metastases treated with stereotactic radiosurgery (SRS). Adv Radiat Oncol. 2017 Nov 24;3(2):146-153. PubMed PMID: 29904739; PubMed Central PMCID: PMC6000027.
      6. Huang J, Campian JL, Gujar AD, Tsien C, Ansstas G, Tran DD, DeWees TA, Lockhart AC, Kim AH. Final results of a phase I dose-escalation, dose-expansion study of adding disulfiram with or without copper to adjuvant temozolomide for newly diagnosed glioblastoma. J Neurooncol. 2018 May;138(1):105-111. PubMed PMID: 29374809.
      7. Taiwo R, Mahlokozera T, Kim AH. Stem nourished by branches: glioblastomas co-opt classic neurotrophic factor signaling to maintain stem-like cell pool. Stem Cell Investig. 2018 Jul 23;5:22. PubMed PMID: 30148155; PubMed Central PMCID: PMC6087708.
      8. Pan Y, Zhu Y, Yang W, Tycksen E, Liu S, Palucki J, Zhu L, Sasaki Y, Sharma MK, Kim AH, Zhang B, Yano H. The role of Twist1 in mutant huntingtin-induced transcriptional alterations and neurotoxicity. J Biol Chem. 2018 Jul 27;293(30):11850-11866. PubMed PMID: 29891550; PubMed Central PMCID: PMC6066321.
      9. Gabani P, Fischer-Valuck BW, Johanns TM, Hernandez-Aya LF, Keller JW, Rich KM, Kim AH, Dunn GP, Robinson CG, Chicoine MR, Huang J, Abraham CD. Stereotactic radiosurgery and immunotherapy in melanoma brain metastases: Patterns of care and treatment outcomes. Radiother Oncol. 2018 Aug;128(2):266-273. PMID: 29960685.
      10. Kamath AA, Friedman DD, Akbari SHA, Kim AH, Tao Y, Luo J, Leuthardt EC. Glioblastoma Treated With Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy: Safety, Efficacy, and Outcomes. Neurosurgery. 2018 Aug 22. PubMed PMID: 30137606.
      11. Beaumont TL, Mohammadi AM, Kim AH, Barnett GH, Leuthardt EC. Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy for Glioblastoma of the Corpus Callosum. Neurosurgery. 2018 Sep 1;83(3):556-565. PMID: 29438526.
      12. Lin AJ, Hui C, Dahiya S, Lu HC, Kim AH, Campian JL, Tsien C, Zipfel GJ, Rich KM, Chicoine M, Huang J. Radiologic Response and Disease Control of Recurrent Intracranial Meningiomas Treated With Reirradiation. Int J Radiat Oncol Biol Phys. 2018 Sep 1;102(1):194-203. PMID: 29970312.
      13. Sterl K, Thompson B, Goss CW, Dacey RG, Rich KM, Zipfel GJ, Chicoine MR, Kim AH, Silverstein JM. Withholding Perioperative Steroids in Patients Undergoing Transsphenoidal Resection for Pituitary Disease: Randomized Prospective Clinical Trial to Assess Safety. Neurosurgery. 2018 Oct 15. PMID: 30325449.
      14. Salehi A, Kamath AA, Leuthardt EC, Kim AH. Management of Intracranial Metastatic Disease with Laser Interstitial Thermal Therapy. Front Oncol. 2018 Oct 31;8:499. PMID: 30430083. PMCID: PMC6220072.
      15. Mohammadi AM, Sharma M, Beaumont TL, Juarez KO, Kemeny H, Dechant C, Seas A, Sarmey N, Lee BS, Jia X, Fecci PE, Baehring J, Moliterno J, Chiang VL, Ahluwalia MS, Kim AH, Barnett GH, Leuthardt EC. Upfront Magnetic Resonance Imaging-Guided Stereotactic Laser-Ablation in Newly Diagnosed Glioblastoma: A Multicenter Review of Survival Outcomes Compared to a Matched Cohort of Biopsy-Only Patients. Neurosurgery. 2018 Nov 23;. doi: 10.1093/neuros/nyy449. [Epub ahead of print] PubMed PMID: 30476325.
      16. McNulty SN, Schwetye K, Goldstein M, Carter J, Schmidt RE, Ansstas G, Tsien CI, Kim AH, Dahiya S. Analysis of point mutations and copy number variation in Grade II and III meningioma. Exp Mol Pathol. 2018 Dec;105(3):328-333. doi: 10.1016/j.yexmp.2018.10.007. Epub 2018 Oct 11. PubMed PMID: 30316860.

      2017

      1. Strowd RE, Kim AH. Meeting update-Society for Neuro-Oncology 2016 annual meeting. Neuro Oncol. 2017 Feb 1;19(2):150-152. PubMed PMID: 28391300; PubMed Central PMCID: PMC5464251.
      2. Rao YJ, Hassanzadeh C, Fischer-Valuck B, Chicoine MR, Kim AH, Perkins SM, Huang J. Patterns of care and treatment outcomes of patients with Craniopharyngioma in the national cancer database. J Neurooncol. 2017 Mar;132(1):109-117. PubMed PMID: 28012064.
      3. Leuthardt EC, Voigt J, Kim AH, Sylvester P. A Single-Center Cost Analysis of Treating Primary and Metastatic Brain Cancers with Either Brain Laser Interstitial Thermal Therapy (LITT) or Craniotomy. Pharmacoecon Open. 2017 Mar;1(1):53-63. PubMed PMID: 29442297; PubMed Central PMCID: PMC5689033.
      4. Kang P, Bucelli RC, Ferguson CJ, Corbo JC, Kim AH, Day GS. Teaching NeuroImages: Cerebral amyloid angiopathy-related inflammation presenting with isolated leptomeningitis. Neurology. 2017 Aug 8;89(6):e66-e67. PubMed PMID: 28784645.
      5. Das S, Kim AH, Chang S, Berger MS. Management of Elderly Patients with Glioblastoma after CE.6. Front Oncol. 2017 Aug 30;7:196. PubMed PMID: 28913179; PubMed Central PMCID: PMC5582080.
      6. Kamath AA, Friedman DD, Hacker CD, Smyth MD, Limbrick DD Jr, Kim AH, Hawasli AH, Leuthardt EC. MRI-Guided Interstitial Laser Ablation for Intracranial Lesions: A Large Single-Institution Experience of 133 Cases. Stereotact Funct Neurosurg. 2017;95(6):417-428. PubMed PMID: 29339639.

      2016

      1. Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE. The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma. Oncotarget. 2016 Jan 12;7(2):2080-92. PubMed PMID: 26716508; PubMed Central PMCID: PMC4811517.
      2. Kang SK, Murphy RK, Hwang SW, Lee SM, Harburg DV, Krueger NA, Shin J, Gamble P, Cheng H, Yu S, Liu Z, McCall JG, Stephen M, Ying H, Kim J, Park G, Webb RC, Lee CH, Chung S, Wie DS, Gujar AD, Vemulapalli B, Kim AH, Lee KM, Cheng J, Huang Y, Lee SH, Braun PV, Ray WZ, Rogers JA. Bioresorbable silicon electronic sensors for the brain. Nature. 2016 Feb 4;530(7588):71-6. PubMed PMID: 26779949.
      3. Leuthardt EC, Duan C, Kim MJ, Campian JL, Kim AH, Miller-Thomas MM, Shimony JS, Tran DD. Hyperthermic Laser Ablation of Recurrent Glioblastoma Leads to Temporary Disruption of the Peritumoral Blood Brain Barrier. PLoS One. 2016 Feb 24;11(2):e0148613. PubMed PMID: 26910903; PubMed Central PMCID: PMC4766093.
      4. Huang J, Campian JL, Gujar AD, Tran DD, Lockhart AC, DeWees TA, Tsien CI, Kim AH. A phase I study to repurpose disulfiram in combination with temozolomide to treat newly diagnosed glioblastoma after chemoradiotherapy. J Neurooncol. 2016 Jun;128(2):259-66. PubMed PMID: 26966095.
      5. Johanns TM, Fu Y, Kobayashi DK, Mei Y, Dunn IF, Mao DD, Kim AH, Dunn GP. High incidence of TERT mutation in brain tumor cell lines. Brain Tumor Pathol. 2016 Jul;33(3):222-7. PubMed PMID: 26960334; PubMed Central PMCID: PMC5605295.
      6. Sun SQ, Cai C, Murphy RK, DeWees T, Dacey RG, Grubb RL, Rich KM, Zipfel GJ, Dowling JL, Leuthardt EC, Simpson JR, Robinson CG, Chicoine MR, Perrin RJ, Huang J, Kim AH. Radiation Therapy for Residual or Recurrent Atypical Meningioma: The Effects of Modality, Timing, and Tumor Pathology on Long-Term Outcomes. Neurosurgery. 2016 Jul;79(1):23-32. PubMed PMID: 26645969.
      7. Pan Y, Daito T, Sasaki Y, Chung YH, Xing X, Pondugula S, Swamidass SJ, Wang T, Kim AH, Yano H. Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity. Sci Rep. 2016 Aug 12;6:31022. in: Sci Rep. 2016 Sep 21;6:33766. PubMed PMID: 27516062; PubMed Central PMCID: PMC4981892.
      8. Pan Y, Daito T, Sasaki Y, Chung YH, Xing X, Pondugula S, Swamidass SJ, Wang T, Kim AH, Yano H. Erratum: Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity. Sci Rep. 2016 Sep 21;6:33766. PubMed PMID: 27649847; PubMed Central PMCID: PMC5030520.
      9. Dadey DY, Kamath AA, Smyth MD, Chicoine MR, Leuthardt EC, Kim AH. Utilizing personalized stereotactic frames for laser interstitial thermal ablation of posterior fossa and mesiotemporal brain lesions: a single-institution series. Neurosurg Focus. 2016 Oct;41(4):E4. PubMed PMID: 27690652.
      10. Sylvester PT, Moran CJ, Derdeyn CP, Cross DT, Dacey RG, Zipfel GJ, Kim AH, Uppaluri R, Haughey BH, Tempelhoff R, Rich KM, Schneider J, Chole RA, Chicoine MR. Endovascular management of internal carotid artery injuries secondary to endonasal surgery: case series and review of the literature. J Neurosurg. 2016 Nov;125(5):1256-1276. PubMed PMID: 26771847.
      11. Gujar AD, Le S, Mao DD, Dadey DY, Turski A, Sasaki Y, Aum D, Luo J, Dahiya S, Yuan L, Rich KM, Milbrandt J, Hallahan DE, Yano H, Tran DD, Kim AH. An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8247-E8256. PubMed PMID: 27930300; PubMed Central PMCID: PMC5187672.

      2015

      1. Speirs CK, Simpson JR, Robinson CG, DeWees TA, Tran DD, Linette G, Chicoine MR, Dacey RG, Rich KM, Dowling JL, Leuthardt EC, Zipfel GJ, Kim AH, Huang J. Impact of 1p/19q codeletion and histology on outcomes of anaplastic gliomas treated with radiation therapy and temozolomide. Int J Radiat Oncol Biol Phys. 2015 Feb 1;91(2):268-76. PubMed PMID: 25636755.
      2. Sylvester PT, Evans JA, Zipfel GJ, Chole RA, Uppaluri R, Haughey BH, Getz AE, Silverstein J, Rich KM, Kim AH, Dacey RG, Chicoine MR. Combined high-field intraoperative magnetic resonance imaging and endoscopy increase extent of resection and progression-free survival for pituitary adenomas. Pituitary. 2015 Feb;18(1):72-85. PubMed PMID: 24599833; PubMed Central PMCID: PMC4161669.
      3. Sun SQ, Hawasli AH, Huang J, Chicoine MR, Kim AH. An evidence-based treatment algorithm for the management of WHO Grade II and III meningiomas. Neurosurg Focus. 2015 Mar;38(3):E3. PubMed PMID: 25727225.
      4. Zygourakis CC, Vasudeva V, Lai PM, Kim AH, Wang H, Du R. Transient pupillary dilation following local papaverine application in intracranial aneurysm surgery. J Clin Neurosci. 2015 Apr;22(4):676-9. PubMed PMID: 25564265.
      5. Sun SQ, Cai C, Ravindra VM, Gamble P, Yarbrough CK, Dacey RG, Dowling JL, Zipfel GJ, Wright NM, Santiago P, Robinson CG, Schmidt MH, Kim AH, Ray WZ. Simpson Grade I-III Resection of Spinal Atypical (World Health Organization Grade II) Meningiomas is Associated With Symptom Resolution and Low Recurrence. Neurosurgery. 2015 Jun;76(6):739-46. PubMed PMID: 25774702.
      6. Mao DD, Gujar AD, Mahlokozera T, Chen I, Pan Y, Luo J, Brost T, Thompson EA, Turski A, Leuthardt EC, Dunn GP, Chicoine MR, Rich KM, Dowling JL, Zipfel GJ, Dacey RG, Achilefu S, Tran DD, Yano H, Kim AH. A CDC20-APC/SOX2 Signaling Axis Regulates Human Glioblastoma Stem-like Cells. Cell Rep. 2015 Jun 23;11(11):1809-21. PubMed PMID: 26074073; PubMed Central PMCID: PMC4481182.
      7. Sengupta R, Barone A, Marasa J, Taylor S, Jackson E, Warrington NM, Rao S, Kim AH, Leonard JR, Piwnica-Worms D, Rubin JB. Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions. Oncotarget. 2015 Jul 30;6(21):18282-92. PubMed PMID: 26286961; PubMed Central PMCID: PMC4621891.
      8. Huang J, DeWees TA, Badiyan SN, Speirs CK, Mullen DF, Fergus S, Tran DD, Linette G, Campian JL, Chicoine MR, Kim AH, Dunn G, Simpson JR, Robinson CG. Clinical and Dosimetric Predictors of Acute Severe Lymphopenia During Radiation Therapy and Concurrent Temozolomide for High-Grade Glioma. Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):1000-1007. PubMed PMID: 26025775.
      9. Gujar AD, Yano H, Kim AH. The CDC20-APC/SOX2 signaling axis: An achilles' heel for glioblastoma. Mol Cell Oncol. 2015 Aug 20;3(3):e1075644. PubMed PMID: 27314081; PubMed Central PMCID: PMC4909416.

      2014

      1. Lin AL, Liu J, Evans J, Leuthardt EC, Rich KM, Dacey RG, Dowling JL, Kim AH, Zipfel GJ, Grubb RL, Huang J, Robinson CG, Simpson JR, Linette GP, Chicoine MR, Tran DD. Codeletions at 1p and 19q predict a lower risk of pseudoprogression in oligodendrogliomas and mixed oligoastrocytomas. Neuro Oncol. 2014 Jan;16(1):123-30. PubMed PMID: 24285548; PubMed Central PMCID: PMC3870829.
      2. Fouke SJ, Benzinger TL, Milchenko M, LaMontagne P, Shimony JS, Chicoine MR, Rich KM, Kim AH, Leuthardt EC, Keogh B, Marcus DS. The comprehensive neuro-oncology data repository (CONDR): a research infrastructure to develop and validate imaging biomarkers. Neurosurgery. 2014 Jan;74(1):88-98. PubMed PMID: 24089052; PubMed Central PMCID: PMC4627592.
      3. Yano H, Baranov SV, Baranova OV, Kim J, Pan Y, Yablonska S, Carlisle DL, Ferrante RJ, Kim AH, Friedlander RM. Inhibition of mitochondrial protein import by mutant huntingtin. Nat Neurosci. 2014 Jun;17(6):822-31. PubMed PMID: 24836077; PubMed Central PMCID: PMC4174557.
      4. Brooks MD, Jackson E, Warrington NM, Luo J, Forys JT, Taylor S, Mao DD, Leonard JR, Kim AH, Piwnica-Worms D, Mitra RD, Rubin JB. PDE7B is a novel, prognostically significant mediator of glioblastoma growth whose expression is regulated by endothelial cells. PLoS One. 2014 Sep 9;9(9):e107397. PubMed PMID: 25203500; PubMed Central PMCID: PMC4159344.
      5. Garsa AA, Badiyan SN, DeWees T, Simpson JR, Huang J, Drzymala RE, Barani IJ, Dowling JL, Rich KM, Chicoine MR, Kim AH, Leuthardt EC, Robinson CG. Predictors of individual tumor local control after stereotactic radiosurgery for non-small cell lung cancer brain metastases. Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):407-13. PubMed PMID: 25084610.
      6. Kim AH, Thompson EA, Governale LS, Santa C, Cahll K, Kieran MW, Chi SN, Ullrich NJ, Scott RM, Goumnerova LC. Recurrence after gross-total resection of low-grade pediatric brain tumors: the frequency and timing of postoperative imaging. J Neurosurg Pediatr. 2014 Oct;14(4):356-64. PubMed PMID: 25062303; PubMed Central PMCID: PMC4858166.
      7. Sun SQ, Cai C, Murphy RK, DeWees T, Dacey RG, Grubb RL, Rich KM, Zipfel GJ, Dowling JL, Leuthardt EC, Leonard JR, Evans J, Simpson JR, Robinson CG, Perrin RJ, Huang J, Chicoine MR, Kim AH. Management of atypical cranial meningiomas, part 2: predictors of progression and the role of adjuvant radiation after subtotal resection. Neurosurgery. 2014 Oct;75(4):356-63; discussion 363. Erratum in: Neurosurgery. 2014 Dec;75(6):733. PubMed PMID: 24932708.
      8. Sun SQ, Kim AH, Cai C, Murphy RK, DeWees T, Sylvester P, Dacey RG, Grubb RL, Rich KM, Zipfel GJ, Dowling JL, Leuthardt EC, Leonard JR, Evans J, Simpson JR, Robinson CG, Perrin RJ, Huang J, Chicoine MR. Management of atypical cranial meningiomas, part 1: predictors of recurrence and the role of adjuvant radiation after gross total resection. Neurosurgery. 2014 Oct;75(4):347-54; discussion 354-5; quiz 355. PubMed PMID: 24932707.
      9. Badiyan SN, Markovina S, Simpson JR, Robinson CG, DeWees T, Tran DD, Linette G, Jalalizadeh R, Dacey R, Rich KM, Chicoine MR, Dowling JL, Leuthardt EC, Zipfel GJ, Kim AH, Huang J. Radiation therapy dose escalation for glioblastoma multiforme in the era of temozolomide. Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):877-85. PubMed PMID: 25257812.
      10. Aum DJ, Kim DH, Beaumont TL, Leuthardt EC, Dunn GP, Kim AH. Molecular and cellular heterogeneity: the hallmark of glioblastoma. Neurosurg Focus. 2014 Dec;37(6):E11. PubMed PMID: 25434380.
      11. Hawasli AH, Kim AH, Dunn GP, Tran DD, Leuthardt EC. Stereotactic laser ablation of high-grade gliomas. Neurosurg Focus. 2014 Dec;37(6):E1. PubMed PMID: 25434378.

      2013

      1. Puram SV*, Kim AH*, Park HY, Anckar J, Bonni A. The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain. Cell Rep. 2013 Jul 11;4(1):19-30. PubMed PMID: 23831032; PubMed Central PMCID: PMC4103748. *contributed equally. 

      Other notable studies

      1. Kong H, Kim AH, Orlinick JR, Chao MV. A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor. Cell Death Differ. 1999 Nov;6(11):1133-42. PubMed PMID: 10578183.
      2. Kim AH, Sheline CT, Tian M, Higashi T, McMahon RJ, Cousins RJ, Choi DW. L-type Ca(2+) channel-mediated Zn(2+) toxicity and modulation by ZnT-1 in PC12 cells. Brain Res. 2000 Dec 15;886(1-2):99-107. PubMed PMID: 11119691.
      3. Kim AH, Khursigara G, Sun X, Franke TF, Chao MV. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol. 2001 Feb;21(3):893-901. PubMed PMID: 11154276; PubMed Central PMCID: PMC86680.
      4. Lee FS, Kim AH, Khursigara G, Chao MV. The uniqueness of being a neurotrophin receptor. Curr Opin Neurobiol. 2001 Jun;11(3):281-6. PubMed PMID: 11399425.
      5. Lee FS, Rajagopal R, Kim AH, Chang PC, Chao MV. Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. J Biol Chem. 2002 Mar 15;277(11):9096-102. PubMed PMID: 11784714.
      6. Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B, Birnbaum MJ, Chao MV. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. 2002 Aug 15;35(4):697-709. PubMed PMID: 12194869.
      7. Kim AH, Sasaki T, Chao MV. JNK-interacting protein 1 promotes Akt1 activation. J Biol Chem. 2003 Aug 8;278(32):29830-6. PubMed PMID: 12783873.
      8. Kim AH, Bonni A. Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous system. Mol Cell Neurosci. 2007 Mar;34(3):281-7. PubMed PMID: 17223572.
      9. Kim AH, Bonni A. Cdk1-FOXO1: a mitotic signal takes center stage in post-mitotic neurons. Cell Cycle. 2008 Dec 15;7(24):3819-22. PubMed PMID: 19124971; PubMed Central PMCID: PMC2868071.
      10. Kim AH, Puram SV, Bilimoria PM, Ikeuchi Y, Keough S, Wong M, Rowitch D, Bonni A. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Cell. 2009 Jan 23;136(2):322-36. PubMed PMID: 19167333; PubMed Central PMCID: PMC2707082.
      11. Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, Chiba AA, Tuszynski MH. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009 Mar;15(3):331-7. PubMed PMID: 19198615; PubMed Central PMCID: PMC2838375.
      12. Yang Y, Kim AH, Yamada T, Wu B, Bilimoria PM, Ikeuchi Y, de la Iglesia N, Shen J, Bonni A. A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science. 2009 Oct 23;326(5952):575-8. PubMed PMID: 19900895; PubMed Central PMCID: PMC2846784.
      13. Puram SV, Kim AH, Bonni A. An old dog learns new tricks: a novel function for Cdc20-APC in dendrite morphogenesis in neurons. Cell Cycle. 2010 Feb 1;9(3):482-5. PubMed PMID: 20195072; PubMed Central PMCID: PMC2853878.
      14. Yang Y, Kim AH, Bonni A. The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity. Curr Opin Neurobiol. 2010 Feb;20(1):92-9. PubMed PMID: 20060286; PubMed Central PMCID: PMC3118470.
      15. Puram SV, Kim AH, Ikeuchi Y, Wilson-Grady JT, Merdes A, Gygi SP, Bonni A. A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain. Nat Neurosci. 2011 Jul 3;14(8):973-83. PubMed PMID: 21725312; PubMed Central PMCID: PMC3391735.
      16. Puram SV, Riccio A, Koirala S, Ikeuchi Y, Kim AH, Corfas G, Bonni A. A TRPC5-regulated calcium signaling pathway controls dendrite patterning in the mammalian brain. Genes Dev. 2011 Dec 15;25(24):2659-73. PubMed PMID: 22135323; PubMed Central PMCID: PMC3248686.

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      Photos from lab events

      Lab meeting, 2018
      Genetics Holiday Party, 2018
      Kim and Yano Holiday Party, 2018
      Kim and Yano Holiday Party, 2018
      Kim and Yano labs, 2013
      Albert Kim, Diane Mao, Anne Thompson, 2012
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